Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.
Identifieur interne : 000830 ( Main/Exploration ); précédent : 000829; suivant : 000831Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.
Auteurs : Yasser Sakr [Allemagne] ; Manuela Giovini [Italie] ; Marc Leone [France] ; Giacinto Pizzilli [Italie] ; Andreas Kortgen [Allemagne] ; Michael Bauer [Allemagne] ; Tommaso Tonetti [Italie] ; Gary Duclos [France] ; Laurent Zieleskiewicz [France] ; Samuel Buschbeck [Allemagne] ; V Marco Ranieri [Italie] ; Elio Antonucci [Italie]Source :
- Annals of intensive care [ 2110-5820 ] ; 2020.
Abstract
Background
Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).
Main text
We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.
Conclusion
Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.
DOI: 10.1186/s13613-020-00741-0
PubMed: 32953201
PubMed Central: PMC7492788
Affiliations:
- Allemagne, France, Italie
- Provence-Alpes-Côte d'Azur, Émilie-Romagne
- Bologne, Marseille
- Université d'Aix-Marseille, Université de Bologne
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.</title><author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Giovini, Manuela" sort="Giovini, Manuela" uniqKey="Giovini M" first="Manuela" last="Giovini">Manuela Giovini</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author><author><name sortKey="Leone, Marc" sort="Leone, Marc" uniqKey="Leone M" first="Marc" last="Leone">Marc Leone</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Pizzilli, Giacinto" sort="Pizzilli, Giacinto" uniqKey="Pizzilli G" first="Giacinto" last="Pizzilli">Giacinto Pizzilli</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Kortgen, Andreas" sort="Kortgen, Andreas" uniqKey="Kortgen A" first="Andreas" last="Kortgen">Andreas Kortgen</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Tonetti, Tommaso" sort="Tonetti, Tommaso" uniqKey="Tonetti T" first="Tommaso" last="Tonetti">Tommaso Tonetti</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Zieleskiewicz, Laurent" sort="Zieleskiewicz, Laurent" uniqKey="Zieleskiewicz L" first="Laurent" last="Zieleskiewicz">Laurent Zieleskiewicz</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Buschbeck, Samuel" sort="Buschbeck, Samuel" uniqKey="Buschbeck S" first="Samuel" last="Buschbeck">Samuel Buschbeck</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V Marco" last="Ranieri">V Marco Ranieri</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32953201</idno><idno type="pmid">32953201</idno><idno type="doi">10.1186/s13613-020-00741-0</idno><idno type="pmc">PMC7492788</idno><idno type="wicri:Area/Main/Corpus">000064</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000064</idno><idno type="wicri:Area/Main/Curation">000064</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000064</idno><idno type="wicri:Area/Main/Exploration">000064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.</title><author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Giovini, Manuela" sort="Giovini, Manuela" uniqKey="Giovini M" first="Manuela" last="Giovini">Manuela Giovini</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author><author><name sortKey="Leone, Marc" sort="Leone, Marc" uniqKey="Leone M" first="Marc" last="Leone">Marc Leone</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Pizzilli, Giacinto" sort="Pizzilli, Giacinto" uniqKey="Pizzilli G" first="Giacinto" last="Pizzilli">Giacinto Pizzilli</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Kortgen, Andreas" sort="Kortgen, Andreas" uniqKey="Kortgen A" first="Andreas" last="Kortgen">Andreas Kortgen</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Tonetti, Tommaso" sort="Tonetti, Tommaso" uniqKey="Tonetti T" first="Tommaso" last="Tonetti">Tommaso Tonetti</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Zieleskiewicz, Laurent" sort="Zieleskiewicz, Laurent" uniqKey="Zieleskiewicz L" first="Laurent" last="Zieleskiewicz">Laurent Zieleskiewicz</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Buschbeck, Samuel" sort="Buschbeck, Samuel" uniqKey="Buschbeck S" first="Samuel" last="Buschbeck">Samuel Buschbeck</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V Marco" last="Ranieri">V Marco Ranieri</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of intensive care</title><idno type="ISSN">2110-5820</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).</p></div><div type="abstract" xml:lang="en"><p><b>Main text</b></p><p>We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32953201</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2110-5820</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Annals of intensive care</Title><ISOAbbreviation>Ann Intensive Care</ISOAbbreviation></Journal><ArticleTitle>Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.</ArticleTitle><Pagination><MedlinePgn>124</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13613-020-00741-0</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).</AbstractText><AbstractText Label="Main text" NlmCategory="UNASSIGNED">We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.</AbstractText><CopyrightInformation>© The Author(s) 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sakr</LastName><ForeName>Yasser</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</Affiliation><Identifier Source="GRID">grid.275559.9</Identifier><Identifier Source="ISNI">0000 0000 8517 6224</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovini</LastName><ForeName>Manuela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leone</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pizzilli</LastName><ForeName>Giacinto</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation><Identifier Source="GRID">grid.6292.f</Identifier><Identifier Source="ISNI">0000 0004 1757 1758</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kortgen</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</Affiliation><Identifier Source="GRID">grid.275559.9</Identifier><Identifier Source="ISNI">0000 0000 8517 6224</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</Affiliation><Identifier Source="GRID">grid.275559.9</Identifier><Identifier Source="ISNI">0000 0000 8517 6224</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tonetti</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation><Identifier Source="GRID">grid.6292.f</Identifier><Identifier Source="ISNI">0000 0004 1757 1758</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duclos</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zieleskiewicz</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buschbeck</LastName><ForeName>Samuel</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743 Jena, Germany.</Affiliation><Identifier Source="GRID">grid.275559.9</Identifier><Identifier Source="ISNI">0000 0000 8517 6224</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranieri</LastName><ForeName>V Marco</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation><Identifier Source="GRID">grid.6292.f</Identifier><Identifier Source="ISNI">0000 0004 1757 1758</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonucci</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Ann Intensive Care</MedlineTA><NlmUniqueID>101562873</NlmUniqueID><ISSNLinking>2110-5820</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Pulmonary embolism</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Thromboprophylaxis</Keyword><Keyword MajorTopicYN="N">Venous thromboembolism</Keyword></KeywordList><CoiStatement>Competing interestsThe authors declare that they do not have conflict of interests in relation to this manuscript.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>10</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32953201</ArticleId><ArticleId IdType="doi">10.1186/s13613-020-00741-0</ArticleId><ArticleId IdType="pii">741</ArticleId><ArticleId IdType="pmc">PMC7492788</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
<ReferenceList><Reference><Citation>Blood. 2014 May 1;123(18):2759-67</Citation><ArticleIdList><ArticleId IdType="pubmed">24585776</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Case Rep Intern Med. 2020 Apr 08;7(5):001646</Citation><ArticleIdList><ArticleId IdType="pubmed">32399449</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood Adv. 2018 Nov 27;2(22):3257-3291</Citation><ArticleIdList><ArticleId IdType="pubmed">30482765</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:153-155</Citation><ArticleIdList><ArticleId IdType="pubmed">32386986</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Sep;296(3):E186-E188</Citation><ArticleIdList><ArticleId IdType="pubmed">32324103</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2020 Aug;26(8):1941-1943</Citation><ArticleIdList><ArticleId IdType="pubmed">32348233</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jun;190:58-59</Citation><ArticleIdList><ArticleId IdType="pubmed">32302782</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 May;18(5):1094-1099</Citation><ArticleIdList><ArticleId IdType="pubmed">32220112</ArticleId></ArticleIdList></Reference><Reference><Citation>Diagn Interv Imaging. 2020 May;101(5):321-322</Citation><ArticleIdList><ArticleId IdType="pubmed">32334995</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Haemost. 2006 Jul;96(1):100-1</Citation><ArticleIdList><ArticleId IdType="pubmed">16807662</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Thromb Hemost. 2020 May 12;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32396963</ArticleId></ArticleIdList></Reference><Reference><Citation>JACC Case Rep. 2020 Jul 15;2(9):1379-1382</Citation><ArticleIdList><ArticleId IdType="pubmed">32313884</ArticleId></ArticleIdList></Reference><Reference><Citation>J Travel Med. 2020 Aug 20;27(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32330267</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Bronconeumol. 2020 Jul;56 Suppl 2:34</Citation><ArticleIdList><ArticleId IdType="pubmed">32386987</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2016 Feb;149(2):315-352</Citation><ArticleIdList><ArticleId IdType="pubmed">26867832</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J. 2020 Jun 7;41(22):2133</Citation><ArticleIdList><ArticleId IdType="pubmed">32374381</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Aug;192:113-115</Citation><ArticleIdList><ArticleId IdType="pubmed">32425261</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Haemost. 2020 May;120(5):876-878</Citation><ArticleIdList><ArticleId IdType="pubmed">32246450</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Jan;18(1):180-190</Citation><ArticleIdList><ArticleId IdType="pubmed">31549765</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Kidney Dis. 2017 Jun;69(6):815-826</Citation><ArticleIdList><ArticleId IdType="pubmed">28242135</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb J. 2020 Apr 20;18:7</Citation><ArticleIdList><ArticleId IdType="pubmed">32336956</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J. 2020 Jun 7;41(22):2134</Citation><ArticleIdList><ArticleId IdType="pubmed">32374405</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood Transfus. 2020 May;18(3):167-169</Citation><ArticleIdList><ArticleId IdType="pubmed">32281926</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:36-37</Citation><ArticleIdList><ArticleId IdType="pubmed">32371163</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2013 Jan;11(1):17-25</Citation><ArticleIdList><ArticleId IdType="pubmed">23114008</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Jun;18(6):1421-1424</Citation><ArticleIdList><ArticleId IdType="pubmed">32271988</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Jul;18(7):1743-1746</Citation><ArticleIdList><ArticleId IdType="pubmed">32320517</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Thorac Surg. 2020 Apr 16;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32305287</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J. 2020 May 14;41(19):1858</Citation><ArticleIdList><ArticleId IdType="pubmed">32227120</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Haematol. 2020 Jun;189(5):846-847</Citation><ArticleIdList><ArticleId IdType="pubmed">32304577</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 Sep 1;173(5):350-361</Citation><ArticleIdList><ArticleId IdType="pubmed">32422076</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Apr;18(4):844-847</Citation><ArticleIdList><ArticleId IdType="pubmed">32073213</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:148-150</Citation><ArticleIdList><ArticleId IdType="pubmed">32381264</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2020 Aug;26(8):1937-1939</Citation><ArticleIdList><ArticleId IdType="pubmed">32396506</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Med. 2020 May 11;9(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32403217</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 May 14;:201955</Citation><ArticleIdList><ArticleId IdType="pubmed">32407256</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 May;18(5):1023-1026</Citation><ArticleIdList><ArticleId IdType="pubmed">32338827</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Esp Cardiol. 2020 Aug;73(8):672-674</Citation><ArticleIdList><ArticleId IdType="pubmed">32834362</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J Cardiovasc Imaging. 2020 Sep 1;21(9):1054</Citation><ArticleIdList><ArticleId IdType="pubmed">32338707</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Thrombolysis. 2020 Jul;50(1):239-241</Citation><ArticleIdList><ArticleId IdType="pubmed">32394237</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Med. 2020 Jun 15;9(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">32549229</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 Aug 18;173(4):268-277</Citation><ArticleIdList><ArticleId IdType="pubmed">32374815</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Emerg Med. 2020 Jul;38(7):1544.e1-1544.e3</Citation><ArticleIdList><ArticleId IdType="pubmed">32312574</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Sep;296(3):E181-E183</Citation><ArticleIdList><ArticleId IdType="pubmed">32324099</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2020 Jun;46(6):1089-1098</Citation><ArticleIdList><ArticleId IdType="pubmed">32367170</ArticleId></ArticleIdList></Reference><Reference><Citation>Fed Pract. 2020 Jun;37(6):e1-e2</Citation><ArticleIdList><ArticleId IdType="pubmed">32489244</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:76-77</Citation><ArticleIdList><ArticleId IdType="pubmed">32402996</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Thorac Surg. 2018 Aug;106(2):404-411</Citation><ArticleIdList><ArticleId IdType="pubmed">29626461</ArticleId></ArticleIdList></Reference><Reference><Citation>Diagn Interv Imaging. 2020 May;101(5):325-326</Citation><ArticleIdList><ArticleId IdType="pubmed">32303472</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2020 Aug 17;222(6):894-898</Citation><ArticleIdList><ArticleId IdType="pubmed">32582936</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:9-14</Citation><ArticleIdList><ArticleId IdType="pubmed">32353746</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Emerg Med. 2020 Jul;38(7):1549.e1-1549.e2</Citation><ArticleIdList><ArticleId IdType="pubmed">32425320</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Sep;296(3):E189-E191</Citation><ArticleIdList><ArticleId IdType="pubmed">32324102</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Thorac Surg. 2020 Apr 28;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32360384</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Haemost. 2014 Jan;111(1):88-93</Citation><ArticleIdList><ArticleId IdType="pubmed">24136071</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2016 Oct;44(10):e930-9</Citation><ArticleIdList><ArticleId IdType="pubmed">27322364</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Esp Cardiol. 2020 Aug;73(8):665-667</Citation><ArticleIdList><ArticleId IdType="pubmed">32834360</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2020 Jun;127:104362</Citation><ArticleIdList><ArticleId IdType="pubmed">32305883</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Aug;18(8):1995-2002</Citation><ArticleIdList><ArticleId IdType="pubmed">32369666</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2020 Jul 30;56(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">32398297</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Oct;297(1):E216-E222</Citation><ArticleIdList><ArticleId IdType="pubmed">32324101</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Med (Lond). 2020 Jul;20(4):e76-e81</Citation><ArticleIdList><ArticleId IdType="pubmed">32423903</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Jul;191:145-147</Citation><ArticleIdList><ArticleId IdType="pubmed">32291094</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973</Citation><ArticleIdList><ArticleId IdType="pubmed">32311448</ArticleId></ArticleIdList></Reference><Reference><Citation>Pol Arch Intern Med. 2020 May 29;130(5):438-439</Citation><ArticleIdList><ArticleId IdType="pubmed">32356640</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 Aug;18(8):1859-1865</Citation><ArticleIdList><ArticleId IdType="pubmed">32459046</ArticleId></ArticleIdList></Reference><Reference><Citation>Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1401-1402</Citation><ArticleIdList><ArticleId IdType="pubmed">32425360</ArticleId></ArticleIdList></Reference><Reference><Citation>J Vasc Surg Venous Lymphat Disord. 2020 Jul;8(4):526-534</Citation><ArticleIdList><ArticleId IdType="pubmed">32305585</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Cardiovasc Med. 2019 Jun 20;6:85</Citation><ArticleIdList><ArticleId IdType="pubmed">31281822</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Haematol. 2020 Jul;190(1):e37-e38</Citation><ArticleIdList><ArticleId IdType="pubmed">32420614</ArticleId></ArticleIdList></Reference><Reference><Citation>Acad Radiol. 2020 Jun;27(6):896-897</Citation><ArticleIdList><ArticleId IdType="pubmed">32331965</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2018 Apr 26;131(17):1903-1909</Citation><ArticleIdList><ArticleId IdType="pubmed">29483100</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J. 2020 May 1;41(32):3107</Citation><ArticleIdList><ArticleId IdType="pubmed">32396627</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2020 Jul 14;142(2):184-186</Citation><ArticleIdList><ArticleId IdType="pubmed">32330083</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Lab Hematol. 2020 Jun;42 Suppl 1:19-20</Citation><ArticleIdList><ArticleId IdType="pubmed">32311843</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 Aug;192:21-22</Citation><ArticleIdList><ArticleId IdType="pubmed">32416365</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Haemost. 2020 Jun;120(6):937-948</Citation><ArticleIdList><ArticleId IdType="pubmed">32316065</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Émilie-Romagne</li></region><settlement><li>Bologne</li><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li><li>Université de Bologne</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name></noRegion><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><name sortKey="Buschbeck, Samuel" sort="Buschbeck, Samuel" uniqKey="Buschbeck S" first="Samuel" last="Buschbeck">Samuel Buschbeck</name><name sortKey="Kortgen, Andreas" sort="Kortgen, Andreas" uniqKey="Kortgen A" first="Andreas" last="Kortgen">Andreas Kortgen</name></country><country name="Italie"><noRegion><name sortKey="Giovini, Manuela" sort="Giovini, Manuela" uniqKey="Giovini M" first="Manuela" last="Giovini">Manuela Giovini</name></noRegion><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><name sortKey="Pizzilli, Giacinto" sort="Pizzilli, Giacinto" uniqKey="Pizzilli G" first="Giacinto" last="Pizzilli">Giacinto Pizzilli</name><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V Marco" last="Ranieri">V Marco Ranieri</name><name sortKey="Tonetti, Tommaso" sort="Tonetti, Tommaso" uniqKey="Tonetti T" first="Tommaso" last="Tonetti">Tommaso Tonetti</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Leone, Marc" sort="Leone, Marc" uniqKey="Leone M" first="Marc" last="Leone">Marc Leone</name></region><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><name sortKey="Zieleskiewicz, Laurent" sort="Zieleskiewicz, Laurent" uniqKey="Zieleskiewicz L" first="Laurent" last="Zieleskiewicz">Laurent Zieleskiewicz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000830 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000830 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32953201
|texte= Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32953201" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |